We use multiple modalities to treat a broad range of food, gastrointestinal (GI), and metabolic-related diseases, including biologics and immunotherapy for the treatment of allergic conditions, because we’re dedicated to advancing science and technology platforms for every challenge.
The global prevalence of allergic disease has risen dramatically over the past 50 years, with up to 40% of the world’s population affected by at least one condition, including asthma; rhinitis; anaphylaxis; allergy to food, drugs, or insects; eczema; and urticaria (hives) and angioedema.1
- Among school-aged children, the rates of sensitization to one or more common allergens is approaching 40-50% worldwide.1
- More than 30 million people in the U.S. currently live with food allergies.2
GI and Metabolic-Related Diseases
We focus on helping patients with GI and metabolic-related diseases who have few or no treatment options. Some of our therapeutic areas of focus include:
Exocrine Pancreatic Insufficiency (EPI)
- Up to 80% of people who've had surgery on their pancreas, stomach, or upper small intestine will develop EPI. Patients with EPI must take Pancreatic Enzyme Replacement Therapies (PERTs) at every meal/snack to ensure proper absorption of nutrients.3
Clostridium difficile (C. diff)
- C. diff is the number one most common microbial cause of healthcare-associated infections in U.S. hospitals and costs up to $4.8 billion each year in excess healthcare costs for acute care facilities alone.4
Inborn Errors of Metabolism (IEMs) - including phenylketonuria (PKU)
- IEMs are estimated to affect one in 800 to one in 2,500 births and place a significant burden on both the patient and family. 5
- There is a one in four chance of having a PKU infant when both parents are genetic carriers.5
- Pawankar R, Canonica WG, Holgate ST, Lockey RF, Blaiss MS. Executive Summary. In: Pawankar R, Canonica WG, Holgate ST, Lockey RF, Blaiss MS. WAO White Book on Allergy: Update 2013. Milwaukee, WI: World Allergy Organization; 2013: 1-9. https://www.worldallergy.org/UserFiles/file/ExecSummary-2013-v6-hires.pdf. Accessed December 15, 2021.
- Facts and Statistics: Key information to help better understand food allergies and anaphylaxis. Food Allergy website. https://www.foodallergy.org/resources/facts-and-statistics. Accessed December 15, 2021.
- Domínguez-Muñoz JE. Pancreatic enzyme replacement therapy: exocrine pancreatic insufficiency after gastrointestinal surgery. HPB (Oxford). 2009;11 Suppl 3(Suppl 3):3-6. doi:10.1111/j.1477-2574.2009.00132.x
- Nearly half a million Americans suffered from Clostridium difficile infections in a single year. Centers for Disease Control and Prevention website. https://www.cdc.gov/media/releases/2015/p0225-clostridium-difficile.html. Updated March 22, 2017. Accessed December 15, 2021.
- Marcdante KJ, Kliegman R, Nelson WE. Nelson Essentials of Pediatrics. 8th ed. Philadelphia (PA), PA: Elsevier; 2019.